Infectious and allergic theory of rheumatism pathogenesis

With all the harmony of the purely allergic theory of rheumatism, it is difficult to imagine that a disease, the triggering factor of which is a microbe, in the future so persistently proceeded according to the type of "autogenic chain reaction", where the body's own cells would continuously play the role of a foreign antigen. Moreover, this disease progresses and is characterized by the development of powerful specific, inflammatory changes that disfigure the heart valves, extensive vascular lesions, connective tissue and the central nervous system. Finally, in the evolutionary development of the disease at any stage, in the clinic and biology, it is possible to identify septic syndrome, confirmed with skillful bacteriological technique by seeding streptococcus from the blood. To object to the infectious theory of rheumatism, the fact of obtaining an experimental Klinge granuloma without the participation of a microbial infection can be used. However, the Klinge granulomas are not completely morphologically identical to the Ashof-Talalaev granulomas and their dynamics are different. If we embrace in our mind's eye the entire complex clinical and anatomical dynamics of rheumatism, the important role of infection in the development and the entire course of rheumatic disease and its complications is recognized. Rheumatism is one of the most insidious chronic cyclical diseases, with which only two diseases - tuberculosis and syphilis — can be compared in treachery and dramatic consequences. There are a lot of similarities between these two diseases and rheumatism, but few people use comparisons between them to reinforce some of the most important theoretical concepts regarding rheumatism.


It is known that reactivity (allergic reactions) is no less important in the extremely variable course of tuberculosis and syphilis than in rheumatism, but it would never occur to anyone to deny the crucial role of pathogens at any stage (with the exception of the metainfective process) in the development of these diseases. Infection plays a decisive and permanent role in the development and course of rheumatism, but also the fact that this infection is specific, and therefore definite. In the very specific nature and peculiar systemic nature of lesions in rheumatism, not just an allergic reaction should be emphasized, but a certain significance of the infectious origin. Here the question arises about the causative agent of rheumatism. As a result of the intervention in the study of this disease by many poorly armed clinical laboratory technicians with genuine bacteriological methods, as well as due to the objective difficulties of bacteriological methods, this issue has not been resolved as soundly as in tuberculosis and syphilis. The variability of reactive phenomena has led to the fact that some clinicians are captivated by the extremely amorphous "polyethological theory", which claims that there are many pathogens of rheumatism. This concept, since it denies the specificity of the disease and the pathogen, logically should return us to the recognition of a purely allergic theory of rheumatism, i.e. the decisive role of reactivity in the development of the disease. How to get no deposit casino bonuses for registration? It is easier than it would seem. Visit the site at the link above, choose an online casino from the list and don't forget to copy the unique promo code. To get a no deposit bonus, you need to specify the promo code in a special field. Don't miss the chance to experience the excitement without risking your money!